Neuroanatomic and neurocognitive phenotype in Williams syndrome

  • Adriana Sampaio Laboratório de Neuropsicofisiologia, CIPsi, Escola de Psicologia, Universidade do Minho, Portugal. Grupo de Medicina Xenómica, Universidade de Santiago de Compostela. España.
  • Ana Osorio Laboratório de Neuropsicofisiologia, CIPsi, Escola de Psicologia, Universidade do Minho, Portugal.
  • Montse Fernández Grupo de Medicina Xenómica, Universidade de Santiago de Compostela. España. Fundación Pública Galega de Medicina Xenómica (SERGAS).
  • Ángel Carracedo Grupo de Medicina Xenómica, Universidade de Santiago de Compostela. España. Fundación Pública Galega de Medicina Xenómica (SERGAS).
  • Elena Garayzábal Departamento de Lingüística, Universidad Autónoma de Madrid, España
  • Catarina Fernandes Laboratório de Neuropsicofisiologia, CIPsi, Escola de Psicologia, Universidade do Minho, Portugal.
  • Cristiana Vasconcelos Departamento de Neurorradiología, CHP-Hospital Santo António, Porto, Portugal
  • Óscar F. Gonçalves Laboratório de Neuropsicofisiologia, CIPsi, Escola de Psicologia, Universidade do Minho, Portugal.
DOI: https://doi.org/10.5209/rlog.58682
Keywords: Brain Structure, MRI, Neurocognition, Williams syndrome.

Abstract

Williams syndrome (WS) is a neurodevelopmental genetic disorder characterized by a dissociation in their cognitive architecture, in which severe visuospatial cognition deficits contrast with relatively preserved language, face recognition, and short-term auditory skills. This cognitive dissociation has also been proposed to characterize their brain structure. In this study, we analysed the structural and neurocognitive phenotype in WS and typically developing groups. Therefore, we analysed the relationship between brain white matter, grey matter and regions of interest (superior temporal gyrus and hippocampus) with neurocognitive functioning. The results of this study showed differences between with respect to the type of correlations observed for WS and typically developing groups. These differences in the pattern of association between cognitive and brain measures suggest altered neurodevelopmental patterns in WS.

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Published
2013-05-14
How to Cite
Sampaio A., Osorio A., Fernández M., Carracedo Á., Garayzábal E., Fernandes C., Vasconcelos C. y Gonçalves Ó. F. (2013). Neuroanatomic and neurocognitive phenotype in Williams syndrome. Revista de Investigación en Logopedia, 3(1), 18-33. https://doi.org/10.5209/rlog.58682
Issue
Vol. 3 No. 1 (2013)
Section
Artículos

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