Histologycal study of the development of the cerebellum
Abstract
We study the histological cerebellar development in rats and we compared it chronologically to humans. The cerebellum derives from the hindbrain, and its origin occurs in Er15d/Eh8w (embryo days/weeks). Sources of neurons in the cerebellum are: 1) subventricular region where precursors of Purkinje neurons migrate radially towards to the dorsal surface of the cerebellar anlage, where they organize in several layers (Er18d/Eh13w). Later, Purkinje neurons arranged in a unique layer (Pr6d/Eh30w; Postnatal); 2) rostral part of the rhombic lip, from which granule cells precursors migrate tangentially to constitute the external granular layer (EGL) located next to the dorsal area of the cerebellar anlage (Er17d/Eh10w). EGL granule cells migrate to a deeper possition, overcoming the Purkinje layer to form the internal granule layer (IGL) (Pr0-1d/Eh20w). Subsequently EGL disappears (Pr20d/Ph7months), establishing a single granular layer. The primary lamination starts in Er20-21d/Eh12w and secondary lamination in Pr0-1d/Eh15w.
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