Use of nanoparticles in formulations of acyclovir
Abstract
Herpes simplex virus (1 and 2) is a DNA virus which is replicated in epithelial cells and it has the ability to enter latency. Immunosuppression can caused its reactivation. Acyclovir (ACV) is a synthetic analog of the nucleoside 2´desoxiguanosine that inhibits viral DNA polymerase. Actually, is the most used medication for the treatment of the herpes simplex virus. However, oral bioavailability of acyclovir is limited, primarily because of low permeability across the gastrointestinal membrane. It also has poor permeation properties because of its hydrophilicity. In order to solve this, using nanoparticles in the formulation is studying for improving the efficiency of acyclovir. It helps to obtain smaller particle size, which makes the absorption better and helps the active substance to arrive to the target site.Downloads
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