Age-related changes in oxidate stress parametres in blood cells from men and women
Abstract
Aging underlying to a chronic oxidative situation. The aim of this work was to study the age-related changes in antioxidants, oxidants and oxidative damage in human blood cells. In peripheral blood cells obtained from 95 women and 85 men, who were divided into different age groups: young-(20-29 years), adults-(30-49), mature-(50-69), older-(70-89) and long-lived-(≥90), the activities of the antioxidant enzymes catalase (CAT), glutathione peroxidase (GPx) and reductase (GR) were evaluated, as well as the levels of reduced (GSH), oxidized (GSSG) and total (TG) glutathione, and the levels of malondialdehyde (MDA), a marker of oxidative damage to lipids. In general, in both sexes, an age-related decreased in CAT and GR activities and in the GSH and GT levels, as well as increased levels of GSSG and MDA and of the GSSG/GSH coeficient, were observed. These alterations were more marked in mature, whereas the long-lived sujects showed similar values to young.
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