Acute and preventive protective effect of melatonin against inflammatory and apoptotic hippocampus response to ischemic brain injury induced by middle cerebral artery blockade in aging rats

  • P. Muñoz Departamento de Bioquímica y Biología Molecular III. Facultad de Medicina. Universidad Complutense de Madrid
  • B. Bermudo Departamento de Bioquímica y Biología Molecular III. Facultad de Medicina. Universidad Complutense de Madrid
  • P.M. Shahani Departamento de Bioquímica y Biología Molecular III. Facultad de Medicina. Universidad Complutense de Madrid
  • I. García Departamento de Bioquímica y Biología Molecular III. Facultad de Medicina. Universidad Complutense de Madrid
  • S.D. Paredes Departamento de Bioquímica y Biología Molecular III. Facultad de Medicina. Universidad Complutense de Madrid
  • L. Rancan Departamento de Bioquímica y Biología Molecular III. Facultad de Medicina. Universidad Complutense de Madrid
DOI: https://doi.org/10.5209/RCCV.55221
Keywords: Stroke, melatonin, ischemia/reperfusion injury, oxidative stress

Abstract

The present study aimed to compare the effect of preventive vs. acute melatonin administration on hippocampus ischemic injury of aging rats. 18 months old Wistar rats were subjected to middle cerebral artery obstruction (MCAO). Expression of TNF-α, IL-1β, GFAP, BAD, and BAX increased significantly in hippocampus after MCAO whereas SIRT1 and Bcl2 significantly decreased. PrevT animals experienced a significant decrease in TNF-α, IL- 1β, BAD, and BAX. AT decreased BAD and BAX expression in the contralateral hippocampus with no effect ipsilaterally. Melatonin counteracted hippocampal decrease of SIRT1. This effect was more evident in PrevT group. Our results suggest that melatonin could be a valuable therapeutic agent that may protect the elderly from the damaging effects of brain stroke.

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How to Cite
Muñoz P., Bermudo B., Shahani P., García I., Paredes S. y Rancan L. (2017). Acute and preventive protective effect of melatonin against inflammatory and apoptotic hippocampus response to ischemic brain injury induced by middle cerebral artery blockade in aging rats. Revista Complutense de Ciencias Veterinarias, 11(Especial), 101-106. https://doi.org/10.5209/RCCV.55221
Issue
Vol. 11 No. Especial (2017)
Section
Articles

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