Amigdalar noradrenergic hyperactivation in the physiopatology of a post-traumatic stress disorder animal model
Abstract
The hyperarousal symptomatology in Post-traumatic Stress Disorder (PTSD) can be reproduced in rats using the animal model “Inescapable Foot Shock (IFS)”. The aim of this study is to investigate the role of the noradrenaline in the hyperarousal physiopathology through stress sensitivity (decreased stress threshold). For this goal Wistar rats were exposed to IFS in order to study the hyperarousal response in an OpenField and the ability of intraamigdalar propranolol infusion to ameliorate it, as well as the amigdalar noradrenaline reactivity during an acute inespecific stress (acute restrain). In the rat group exposed to IFS was observed, opposed to the non-exposed: 1) a decrease of locomotion in the first 5 minutes, which was reverted after amigdalar propanolol infusion. 2) an enhanced amigdalar noradrenaline reactivity to an acute inespecific stress. This data demonstrate that amigdalar noradrenaline has a relevant role in the hyperarousal symptoms after exposure to IFS.
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