Cognitive deficits associated to brain changes secondary to oncological therapies
Keywords:
Cancer, Cognitive impairment, chemotherapy, leukoencephalopathy, Neurogenesis, radiotherapy, white matter.
Abstract
Recent advances in surgery, radiation and pharmacology have brought an increase on the rate of survival from cancer. However, it is frequent to see patients affected by cognitive impairments and behavioral changes after chemotherapy and radiology treatments. These changes might be related to injury to the brain tissue, especially to the white matter, caused by such oncological therapies. This work examines the neurobiological processes that underlie the mentioned neuropsychological impairments, such as the hippocampal neurogenesis inhibition, the destruction of oligodendrocytes precursors, as well as changes in white matter. Cognitive dysfunction sequelae in the form of deficits on attention, speed of information processing, memory, and executive functions are also studied.Downloads
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How to Cite
Gómez-Cruz M. (2012). Cognitive deficits associated to brain changes secondary to oncological therapies. Psicooncología, 8(2-3), 215-229. https://doi.org/10.5209/rev_PSIC.2011.v8.n2-3.37878
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