Canalopatías en la epilepsia idiopática monogénica en perros

Abstract

Epilepsy is a common neurological disorder both dogs and humans. Nevertheless, unlike occurs in humans, in dogs it is a badly characterized disease. In humans, it is known from some time ago, that some idiopathic epilepsies present patterns of mendelian inheritance, i.e., caused by the mutation in single genes. The majority of these mutations are in genes codifying by ion channels, being consider as channelopathies. In dogs, the predisposition of some breeds to suffer the disease has aimed to some research groups to study the hereditary basis of idiopathic epilepsy. This review summarizes some aspects relating to the interest to tackle the study of channelopathies in monogenic idiopathic epilepsy in dogs and shows its potential as future diagnostic or therapeutic targets.