An Immunochemical Approach to Model and Long-Term Suppression of Depressive and Anxiety Behavior

  • Igor P. Ashmarin
  • Raisa A. Danilova
  • Olga I. Rud’ko
  • Maria V. Belopolskaya
  • Maria F. Obukhova
  • Elena V. Shmalgausen
Palabras clave: Depression, Modeling, Immuno-correction, Active immunization, Cholecystokinin-4, Isatin, Biogenic amines, Rats

Resumen

The inhibitor of monoaminooxydase isatin and the ligand of B-receptors cholecystokinin- 4 play a significant role in the suppression and induction of depressive and anxiety states. We induced the formation of auto-antibodies to these compounds against their conjugates with antigen-carrier by immunization of white rats. The result was long-term (more than 2 months) stimulation of depressive and anxiety behavior after immunization to isatin and, in contrast, the suppression of such behavior after immunization to cholecystokinin. The perspective of immunochemical approach to long-term correction of behavior is discussed.

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Publicado
2006-11-24
Cómo citar
Ashmarin I. P. ., Danilova R. A. ., Rud’ko O. I. ., Belopolskaya M. V. ., Obukhova M. F. . y Shmalgausen E. V. . (2006). An Immunochemical Approach to Model and Long-Term Suppression of Depressive and Anxiety Behavior. The Spanish Journal of Psychology, 9(2), 219-227. https://revistas.ucm.es/index.php/SJOP/article/view/SJOP0606220219A
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