An Immunochemical Approach to Model and Long-Term Suppression of Depressive and Anxiety Behavior

Resumen

The inhibitor of monoaminooxydase isatin and the ligand of B-receptors cholecystokinin- 4 play a significant role in the suppression and induction of depressive and anxiety states. We induced the formation of auto-antibodies to these compounds against their conjugates with antigen-carrier by immunization of white rats. The result was long-term (more than 2 months) stimulation of depressive and anxiety behavior after immunization to isatin and, in contrast, the suppression of such behavior after immunization to cholecystokinin. The perspective of immunochemical approach to long-term correction of behavior is discussed.